IMPACT OF READY TO USE FOOD SUPPLEMENTS (RUFS) ON THE RATIO OF SOLUBLE FMS LIKE TYROSINE KINASE-1 (SFLT-1) TO PLACENTAL GROWTH FACTOR IN PRE-ECLAMPTIC WOMEN FOR SIX MONTHS

Abstract

Purpose: Pre-eclampsia (PE) defined as an increased hypertension, proteinuria and edema following 20 weeks of gestation. It depends on the angiogenic biomarkers with the normal ratio (sFLT-1 / PlGF) less than 38, abnormality in the levels is positively correlated with the severity of preeclampsia and undesirable fetal (preterm delivery) and maternal outcome much before appearing the clinical signs and symptoms of the disease. Nutrients such as enriched with HDL, calcium, iron, iodine, copper, manganese and Omega-3 unsaturated fats play an important role in decreasing the danger of the pre-eclampsia. Objectives: In our study, we want to identify the correlation of nutritional lipid-based supplements (LNS) on the impact of angiogenic factors that are associated with pre-eclampsia. Study Design: Randomized contral trial. Setting: Saidu group of teaching Hospital Swat. Period: Jan to Jun 2018. Material & Methods: A total of eightyfour (n=84) pre-eclamptic participants with positive test of proteinuria (pre-selection) were recruited for our study sFLT-1 &PlGF levels was measured with commercially available ELISA kit (CatLog). Result: Mean concentration of control before [sFLT-1, 68±215-PlGF, 107±63 pg/ml] & after [sFLT-1, 161±322-PlGF, 104±57 pg/ml]. While interventional before [sFLT-1, 57±207 PlGF, 97±54 pg/ml] & after [sFLT-1, 184±866-PlGF, 107±113 pg/ml]. Weight and BMI was strongly significant. Ratio (sFLT-1/ PlGF) was positive in after intervention between control and intervention arm. Conclusion: In conclusion, Cut-offs score with the changes in sFlt-1/PlGF ratio may clinically utilize these markers for PE pregnancies with or without intervention (LNS). sFlt- 1/PlGF proportion is more critical among control and intervention with an unaltered mean PlGF level in control pre-eclamptic patients. We infer that the analytic window in the utilization of the sFlt-1/PlGF ratio differs with LNS supplementation.